Mayo Clinic Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top Holiday Package Deals in Mayo Clinic
Price found within the past 48 hours. Click for updated prices.
Mountain Shadows Resort Scottsdale
Price was CA $1,081, price is now CA $751 per person
CA $751
per person
Jun 4 - Jun 8
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Phoenix (PHX)
9.8/10 Exceptional! (1,093 reviews)
Love the big rooms. Spacious. Good location. Beautiful property
Reviewed on Apr 25, 2026
Home2 Suites by Hilton Phoenix Tempe, University Research Park
South Tempe
Price was CA $1,137, price is now CA $760 per person
CA $760
per person
Jun 30 - Jul 6
found 9 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to Phoenix (PHX)
8.8/10 Excellent! (557 reviews)
We had to ask after being there for 3 full days (going on 4) for housekeeping to come in and change bedding and give more towels. Front desk was very nice along with kitchen staff during the continental breakfast. However, the hot items on the breakfast weren’t good and were barely warm. I didn’t expect much from a continental breakfast but the eggs were very powdery.
Reviewed on Mar 8, 2026
Grand Hyatt Scottsdale Resort
Gainey Ranch
Price was CA $1,493, price is now CA $1,026 per person
CA $1,026
per person
Jun 30 - Jul 6
found 9 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to Phoenix (PHX)
8.6/10 Excellent! (1,003 reviews)
Staying at the Scottsdale Hyatt was great. The staff were extremely helpful for suggestion options to go out, where to eat, and staying safe on the heat.
Reviewed on Mar 30, 2026
Hotel Valley Ho
Old Town
Price was CA $1,209, price is now CA $835 per person
CA $835
per person
Jun 6 - Jun 12
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to Phoenix (PHX)
9.6/10 Exceptional! (2,380 reviews)
Another great stay at The Valley Ho! The highlight, as always, is the staff—Brendon, Carlos, and the valet team were welcoming and attentive from the moment we arrived, and the front desk made our early check-in effortless.
The rooms are spotless, and the beds and pillows are incredibly comfortable. The food and drinks at the bar were excellent, and a big thank you to Verg, Andy 1, Andy 2, and Sam for the outstanding service.
The team here truly makes the experience—we’ll definitely be back next year.
Reviewed on Apr 27, 2026
Fairmont Scottsdale Princess
Price was CA $2,010, price is now CA $1,420 per person
CA $1,420
per person
Jun 30 - Jul 6
found 9 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to Phoenix (PHX)
9.2/10 Wonderful! (1,007 reviews)
This was a quick family getaway for some sun, great food and a little luxury. We found it all here and loved our stay.
Beautiful space, luxurious without being pretentious. We found our room and the main areas to be well-maintained and clean. The pools are immaculate and well-attended.
Food was awesome. Dinner at Bourbon Steak was unreal. It's a high-end steakhouse with more depth to the menu than a steakhouse normally has. And who doesn't love amazing cocktails??? Our meal was made even better by some of the best service I've enjoyed in any restaurant. Our man Milan was amazing, friendly and could teach a masterclass in sales and customer service.
I also wanted to mention Gabriela who handled our check-in with all of the warmth and professionalism that you want when you arrive for your vacation.
Highly recommended for families, couples or a getaway with friends.
Reviewed on Apr 27, 2026
Where to stay in Mayo Clinic
Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most. Learn more about Mayo Clinic
Downtown Phoenix
3 out of top 10 points of interest in this area
A true urban neighborhood, Downtown Phoenix boasts major sports venues like Chase Field and Footprint Center, as well as cultural attractions such as the Arizona Science Center and Phoenix Art Museum. Easily accessible via Valley Metro Light Rail, enjoy walkable streets, friendly cafes, and local businesses.
Mayo Clinic Hotel Deals
Hilton Phoenix Tapatio Cliffs Resort
11111 N 7th St Phoenix AZ
Fully refundableReserve now, pay when you stay
The price is CA $161 per night from May 24 to May 25
CA $161
CA $242 total
May 24 - May 25
includes taxes & fees
8.6/10 Excellent! (2,552 reviews)
Flooring/carpeting in room was dirty. They need a good shampooing and/or replaced. Pools were unsupervised, so obnoxious teenagers take over the hot tubs and typical families cannot enjoy their time. This happened at least 3 times in different pools across the property. The pool decking and sidewalks ...
Reviewed on Apr 28, 2026
FOUNDRE Phoenix
1100 N Central Avenue Phoenix AZ
Fully refundableReserve now, pay when you stay
The price is CA $173 per night from May 25 to May 26
CA $173
CA $232 total
May 25 - May 26
includes taxes & fees
9/10 Wonderful! (2,493 reviews)
Did not have breakfast was not in the room more than 10 hours of the stay
Reviewed on Apr 27, 2026
Talking Stick Resort
9800 E. Talking Stick Way Scottsdale AZ
The price is CA $219 per night from May 17 to May 18
CA $219
CA $289 total
May 17 - May 18
includes taxes & fees
9.2/10 Wonderful! (4,601 reviews)
Great location near spring training. Clean room and fun atmosphere.
Reviewed on Apr 28, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Discover the most popular places to visit in Mayo Clinic
Arizona State University
Explore the campus of Arizona State University, a top college in Tempe. Amble around the area's lakeside or seek out the jogging trails.
Phoenix Convention Center
During your trip, find out what's happening at Phoenix Convention Center, a top convention center in Phoenix. Experience the fascinating museums and acclaimed art scene in this vibrant area.
Grand Canyon University
Enjoy the collegiate vibe with a visit to Grand Canyon University, a well-known college in Phoenix. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Things to do
SEA LIFE Arizona Aquarium Tickets
CA $24
per adult
84% of travellers recommend
Phoenix Sunrise Hot Air Balloon Ride
CA $344
per adult
96% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.